Ci-Tbx6b and Ci-Tbx6c are key mediators of the maternal effect gene Ci-macho1 in muscle cell differentiation in Ciona intestinalis embryos
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چکیده
منابع مشابه
Quotients of CI-Groups are CI-Groups
We show that a quotient group of a CI-group with respect to (di)graphs is a CI-group with respect to (di)graphs. In [1,2], Babai and Frankl provided strong constraints on which finite groups could be CI-groups with respect to graphs. As a tool in this program, they proved [1, Lemma 3.5] that a quotient group G/N of a CI-group G with respect to graphs is a CI-group with respect to graphs provide...
متن کاملTemporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis.
For over a century, muscle formation in the ascidian embryo has been representative of 'mosaic' development. The molecular basis of muscle-fate predetermination has been partly elucidated with the discovery of Macho1, a maternal zinc-finger transcription factor necessary and sufficient for primary muscle development, and of its transcriptional intermediaries Tbx6b and Tbx6c. However, the molecu...
متن کاملCi-IPF1, the pancreatic homeodomain transcription factor, is expressed in neural cells of Ciona intestinalis larva
We describe the cloning and the expression pattern of insulin promoter factor 1 in the ascidian Ciona intestinalis (Ci-IPF1). Northern blot analysis showed that transcripts appeared at the late tailbud stage and increased at the larval stage. We have raised a specific antibody against the Ci-IPF1-GST fusion protein to determine the spatial expression of this gene. The protein is immunodetected ...
متن کاملIdentification and developmental expression of Ci-msxb: a novel homologue of Drosophila msh gene in Ciona intestinalis
We report the cloning and expression pattern of Ci-msxb the second Ciona intestinalis homeobox gene homologue to the Drosophila muscle segment homeobox (msh) gene. Northern blot analysis showed that transcripts appeared at gastrula stage, peaked in the early tailbud and decreased during the tailed stages. Whole mount in situ hybridization showed that the Ci-msxb expression first is detected at ...
متن کاملRegulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.
Hedgehog (Hh) proteins signal by inhibiting the proteolytic processing of Ci/Gli family transcription factors and by increasing Ci/Gli-specific activity. When Hh is absent, phosphorylation of Ci/Gli triggers binding to SCF ubiquitin ligase complexes and consequent proteolysis. Here we show that multiple successively phosphorylated CK1 sites on Ci create an atypical extended binding site for the...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2005
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.03.029